anti-PSMA monoclonal antibody-MMAE conjugate

{
  "id": "MLC-T-ONC-011052",
  "term": "anti-PSMA monoclonal antibody-MMAE conjugate",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) containing a fully human monoclonal antibody directed against prostate-specific membrane antigen (PSMA), conjugated via a stable, enzyme-cleavable linker to monomethylauristatin E (MMAE), an auristatin derivative and a potent microtubule inhibitor, with potential antineoplastic activity. The monoclonal antibody moiety of this conjugate selectively binds to PSMA, a protein which is abundantly expressed on the surface of metastatic and hormone-refractory prostate cancer cells. Upon internalization and proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and tumor cell apoptosis.",
  "abbreviation": "anti-PSMA-MMAE-ADC",
  "synonyms": [
    "prostate-specific membrane antigen antibody-drug conjugate",
    "anti-PSMA monoclonal antibody-monomethylauristatin E conjugate"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-psma-monoclonal-antibody-mmae-conjugate/"
}