anti-CD22 monoclonal antibody-MMAE conjugate DCDT2980S

{
  "id": "MLC-T-ONC-010309",
  "term": "anti-CD22 monoclonal antibody-MMAE conjugate DCDT2980S",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of MCDT2219A , a humanized IgG1 anti-CD22 monoclonal antibody covalently linked, via a protease-cleavable peptide linker, to monomethyl auristatin E (MMAE), an auristatin derivative and a potent microtubule disrupting agent, with potential antineoplastic activity. Upon administration, the monoclonal antibody moiety of DCDT2980S binds to B-cell-specific CD22 receptors and is rapidly internalized, thereby delivering MMAE intracellularly. Upon proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and tumor cell apoptosis. CD22, a cell surface glycoprotein, is expressed on mature B-cells and on most malignant B-cells.",
  "synonyms": [
    "antibody-drug conjugate DCDT2980S",
    "ADC DCDT2980S"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd22-monoclonal-antibody-mmae-conjugate-dcdt2980s/"
}