anti-CD19/CD20 bicistronic CAR T cells

{
  "id": "MLC-T-ONC-010269",
  "term": "anti-CD19/CD20 bicistronic CAR T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of T lymphocytes that have been transduced with a bicistronic vector encoding two distinct chimeric antigen receptors (CARs), one against the tumor-associated antigen (TAA) CD19 and the other one against the TAA CD20, with potential immunomodulating and antineoplastic activities. Upon administration, the anti-CD19/CD20 bicistronic CAR T cells target, bind to and induce selective toxicity in tumor cells expressing CD19 and/or CD20. CD19 and CD20, both transmembrane phosphoglycoproteins expressed on the surface of cells in the B lineage, are often overexpressed on malignant B cells. By simultaneously targeting two B-cell antigens using two different CARs, this preparation may minimize relapse due to single antigen loss in patients with B-cell malignancies.",
  "synonyms": [
    "CD19/CD20 bicistronic CAR-transduced T cells",
    "CD19x20 bicistronic CAR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd19-cd20-bicistronic-car-t-cells/"
}