anti-CD19/CD20/CD22 CAR T cells

{
  "id": "MLC-T-ONC-010271",
  "term": "anti-CD19/CD20/CD22 CAR T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of human T lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigens (TAAs) cluster of differentiation 19 (CD19), CD20 and CD22, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD19/CD20/CD22 CAR T cells target and bind to CD19, CD20 and CD22 expressed on the surface of certain tumor cells. This induces selective toxicity in tumor cells expressing these TAAs. The TAAs are overexpressed in certain hematologic malignancies.",
  "synonyms": [
    "anti-CD19/20/22 chimeric antigen receptor T cells",
    "CD19/CD20/CD22-targeted CAR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd19-cd20-cd22-car-t-cells/"
}