Autologous anti-CD19 CAR-CD8alpha-CD28-CD3zeta T cells KYV 101

{
  "id": "MLC-T-ONC-011363",
  "term": "Autologous anti-CD19 CAR-CD8alpha-CD28-CD3zeta T cells KYV 101",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous CD4- and CD8-positive T cells that are transduced with a lentiviral vector encoding for a chimeric antigen receptor (CAR) consisting of a human single chain variable fragment (scFv) of anti-CD19 and fused to the hinge and transmembrane domains of CD8alpha co-receptor, the cytoplasmic costimulatory domain of human CD28, and the T-cell antigen receptor complex zeta chain (CD3-zeta), with potential immunostimulating activity. Upon transfusion, autologous anti-CD19 CAR-CD8alpha-CD28-CD3zeta T cells KYV 101 recognize and induce selective toxicity and lysis in CD19-expressing B-cells. CD19, a B-cell-specific cell surface antigen, is overexpressed in B-cell lineage malignancies and in certain B-cell-driven autoimmune diseases.",
  "synonyms": [
    "autologous anti-CD19 CAR T cells KYV 101",
    "autologous anti-CD19 CAR-T cells KYV 101"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cd19-car-cd8alpha-cd28-cd3zeta-t-cells-kyv-101/"
}