anti-TRBC1-CAR-CD3zeta-4-1BB-RQR8-expressing autologous T lymphocytes AUTO4

{
  "id": "MLC-T-ONC-011147",
  "term": "anti-TRBC1-CAR-CD3zeta-4-1BB-RQR8-expressing autologous T lymphocytes AUTO4",
  "field": "Oncology and biomedicine",
  "definition": "Autologous human T lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) containing an anti-T-cell receptor beta constant 1 (TRBC1; T-cell receptor beta-1 chain C region) single chain variable fragment (scFv) and the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunostimulating and antineoplastic activities. Upon administration, anti-TRBC1-CAR-CD3zeta-4-1BB-RQR8-expressing autologous T lymphocytes AUTO4 targets and binds to the TRBC1 expressed on tumor cell surfaces. Subsequently, TRBC1-expressing tumor cells are lysed. In addition, AUTO4 carries the universal RQR8 safety \"off\" switch, which allows selective removal of the T-cells through both complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC) following administration of rituximab if unacceptable side-effects occur.",
  "synonyms": [
    "TRBC1-targeting CAR T cells AUTO4",
    "anti-TRBC1 CAR T cells AUTO4",
    "RQR8/TRBC1 CAR T cells AUTO4"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-trbc1-car-cd3zeta-4-1bb-rqr8-expressing-autologous-t-lymphocytes-auto4/"
}