Autologous gamma-retroviral MSGV1 139 scFv EGFRvIII CAR gene-modified T cells

{
  "id": "MLC-T-ONC-011627",
  "term": "Autologous gamma-retroviral MSGV1 139 scFv EGFRvIII CAR gene-modified T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes transduced with the gamma retroviral vector MSGV1 expressing a chimeric T-cell antigen receptor (CAR) consisting of a single-chain variable fragment (scFv) from a specific antibody clone (mAb139) that targets a mutant form of epidermal growth factor receptor (EGFR) known as variant III (EGFRvIII; EGFR-vIII), with potential antineoplastic activity. Upon intratumoral administration, the gamma-retroviral MSGV1 139 scFv EGFRvIII CAR gene-modified T cells specifically target and bind to tumor cells expressing EGFRvIII, leading to selective cytotoxicity in EGFRvIII-expressing tumor cells. EGFRvIII, a tumor-associated antigen (TAA) encoded by an in-frame deletion of exons 2-7 in the EGFR gene, is specifically overexpressed by a subset of tumor cells and is not expressed in normal, healthy cells. It plays a key role in tumor cell proliferation, tumor angiogenesis and radio- and chemoresistance.",
  "synonyms": [
    "gamma-retroviral MSGV1 139 scFv EGFRvIII CAR gene-modified autologous T lymphocytes",
    "MSGv1-EGFRvIII-CAR autologous T cells",
    "MSGV1-EGFRvIII-specific CAR-transduced autologous T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-gamma-retroviral-msgv1-139-scfv-egfrviii-car-gene-modified-t-cells/"
}