autologous GCC-targeting CAR T Cells GCC19CART

{
  "id": "MLC-T-ONC-011628",
  "term": "autologous GCC-targeting CAR T Cells GCC19CART",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) targeting the enterocyte differentiation antigen guanylyl cyclase C (GUCY2C) that are activated with CAR T cells specific for the CD19 antigen, and coupled to as of yet not fully elucidated signaling domains, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous GCC-targeting CAR T cells GCC19CART are directed to, specifically bind to, activate, proliferate and release cytokines that promote killing of GCC-expressing tumor cells. GCC is overexpressed in various tumor cell types. The activation of the GCC-targeting T cells by activated CD19 CAR that secrete cytokines, enhances CAR T-cell activation and proliferation, and may increase the T-cell-mediated killing of GCC-expressing tumor cells.",
  "synonyms": [
    "anti-GCC autologous CAR T cells GCC19CART",
    "GCC-targeted coupled CAR T cells GCC19CART"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-gcc-targeting-car-t-cells-gcc19cart/"
}