autologous GCC-targeting CAR T cells LCAR-G08

{
  "id": "MLC-T-ONC-011629",
  "term": "autologous GCC-targeting CAR T cells LCAR-G08",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that are genetically engineered, using a lentiviral vector, to express a chimeric antigen receptor (CAR) targeting the enterocyte differentiation antigen guanylyl cyclase C (GUCY2C), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous GCC-targeting CAR T cells LCAR-G08 are directed to, specifically bind to, activate, proliferate and release cytokines that promote killing of GCC-expressing tumor cells. GCC is overexpressed in various tumor cell types.",
  "synonyms": [
    "autologous anti-GCC-CAR T cells LCAR-G08",
    "autologous GCC-targeting CAR-T cells LCAR-G08",
    "autologous GUCY2C-targeting CAR T cells LCAR-G08",
    "LCAR-G08 Cells",
    "LCAR-G08T"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-gcc-targeting-car-t-cells-lcar-g08/"
}