autologous retroviral vector MSGV1-transduced anti-PSCA-8T28Z CAR gamma delta T cells

{
  "id": "MLC-T-ONC-011762",
  "term": "autologous retroviral vector MSGV1-transduced anti-PSCA-8T28Z CAR gamma delta T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous gamma delta T lymphocytes transduced with the gamma retroviral vector MSGV1 expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) prostate stem cell antigen (PSCA), and expressing a hinge/transmembrane domain derived from CD8alpha (CD8a) and a single co-stimulatory domain derived from CD28 (8t28z), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous retroviral vector MSGV1-transduced anti-PSCA-8T28Z CAR gamma delta T cells specifically target, bind to and kill tumor cells expressing PSCA. PSCA is a glycosyl-phosphatidylinositol (GPI)-linked cell surface antigen found in various cancers.",
  "synonyms": [
    "autologous MSGV1-PSCA-8T28Z gdCAR T cells",
    "genetically-modified gamma-retroviral MSGV1-PSCA-8T28Z CAR autologous gamma delta T lymphocytes",
    "MSGv1-PSCA-8T28Z CAR autologous gdT cells",
    "MSGV1-PSCA-8T28Z specific CAR-transduced autologous gamma delta T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-retroviral-vector-msgv1-transduced-anti-psca-8t28z-car-gamma-delta-t/"
}