anti-MUC17/CD3 BiTE antibody AMG 199

{
  "id": "MLC-T-ONC-010906",
  "term": "anti-MUC17/CD3 BiTE antibody AMG 199",
  "field": "Oncology and biomedicine",
  "definition": "A half-life extended (HLE), human bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) human mucin 17 (MUC17), and one directed against human CD3, a T-cell surface antigen found on T lymphocytes, with potential antineoplastic activity. Upon administration, anti-MUC17/CD3 BiTE antibody AMG 199 binds to both CD3 on T cells and MUC17 expressed on tumor cells. This results in the cross-linking of T cells and tumor cells, and induces a potent cytotoxic T-lymphocyte (CTL) response against MUC17-expressing tumor cells. MUC17, a member of the mucin family of glycoproteins, is overexpressed in a variety of tumor cells of epithelial origin and plays a key role in tumor cell dissemination.",
  "synonyms": [
    "MUC17xCD3 bispecific T-cell engager AMG 199",
    "BiTE antibody AMG 199",
    "bispecific T-cell engager antibody AMG 199",
    "MUC17/CD3-directed bispecific T-cell engager antibody AMG 199",
    "anti-MUC17 x anti-CD3 BiTE AMG 199",
    "anti-MUC17/CD3 bispecific antibody AMG 199"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-muc17-cd3-bite-antibody-amg-199/"
}