anti-CLDN6/CD3 BiTE antibody AMG 794

{
  "id": "MLC-T-ONC-010523",
  "term": "anti-CLDN6/CD3 BiTE antibody AMG 794",
  "field": "Oncology and biomedicine",
  "definition": "A half-life extended (HLE) human bispecific T-cell engager (BiTE) antibody targeting the CD3 antigen expressed on T lymphocytes and the cell surface protein claudin 6 (CLDN6; CLDN-6), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, anti-CLDN6/CD3 BiTE antibody AMG 794 targets and binds to both CD3 expressed on T cells and CLDN6 expressed on tumor cells. This activates and redirects cytotoxic T lymphocytes (CTLs) to CLDN6-expressing tumor cells, produces cytokines and leads to enhanced CTL-mediated elimination of CLDN6-expressing tumor cells. CLDN6, a tight-junction protein and embryonic antigen, is expressed on a variety of tumor cells but is not expressed on normal, healthy adult cells.",
  "synonyms": [
    "CLDN6xCD3 bispecific T-cell engager AMG 794",
    "CLDN6/CD3 bispecific T-cell engager AMG 794"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cldn6-cd3-bite-antibody-amg-794/"
}