anti-CLDN6/CD3 bispecific antibody CTIM-76

{
  "id": "MLC-T-ONC-010520",
  "term": "anti-CLDN6/CD3 bispecific antibody CTIM-76",
  "field": "Oncology and biomedicine",
  "definition": "An Fc-silenced humanized immunoglobulin G1 (IgG1) bispecific antibody targeting both the tumor-associated antigen (TAA) claudin 6 (CLDN6; CLDN-6) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, anti-CLDN6/CD3 bispecific antibody CTIM-76 targets and binds to both CLDN6 expressed on tumor cells and CD3 expressed on T cells. This activates and redirects cytotoxic T lymphocytes (CTLs) to CLDN6-expressing tumor cells, which leads to enhanced CTL-mediated killing of CLDN6-expressing tumor cells. CLDN6, a tight-junction protein and embryonic antigen, is overexpressed on a variety of tumor cells but is not or minimally expressed on normal, healthy adult cells.",
  "synonyms": [
    "anti-CD3/CLDN6 bispecific antibody CTIM-76",
    "anti-Claudin-6/CD3 bispecific antibody CTIM-76",
    "anti-CLDN6/anti-CD3 bispecific antibody CTIM-76",
    "anti-CLDN6/CD3 T-cell engaging bispecific antibody CTIM-76",
    "Claudin-6-directed bispecific antibody CTIM-76",
    "CLDN6 T-cell engager antibody CTIM-76",
    "CLDN6 x CD3 bispecific antibody CTIM-76",
    "CLDN6 x CD3 T-cell engaging bispecific antibody CTIM-76",
    "CLDN6-directed TCE CTIM-76"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cldn6-cd3-bispecific-antibody-ctim-76/"
}