anti-CLDN6 monoclonal antibody ASP1650

{
  "id": "MLC-T-ONC-010518",
  "term": "anti-CLDN6 monoclonal antibody ASP1650",
  "field": "Oncology and biomedicine",
  "definition": "A monoclonal antibody directed against the cell surface protein claudin 6 (CLDN6), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CLDN6 monoclonal antibody ASP1650 binds to CLDN-6 and may stimulate the immune system to exert both an antibody-dependent cellular cytotoxicity (ADCC) and a complement-dependent cytotoxicity (CDC) mediated immune response against CLDN-6-expressing tumor cells. This may inhibit tumor cell growth. CLDN-6, a tight-junction protein and embryonic antigen, is expressed on a variety of tumor cells but is not expressed on normal, healthy adult cells.",
  "synonyms": [
    "anti-Claudin 6 monoclonal antibody ASP1650"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cldn6-monoclonal-antibody-asp1650/"
}