autologous anti-CLDN6 CAR-NK cells

{
  "id": "MLC-T-ONC-011416",
  "term": "autologous anti-CLDN6 CAR-NK cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous natural killer (NK) cells engineered to express a chimeric antigen receptor (CAR) specific for the cell surface protein claudin 6 (CLDN6), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CLDN6 CAR-NK cells target and bind to CLDN6 expressed on the surface of tumor cells. This induces selective toxicity in tumor cells expressing CLDN6. CLDN6, a tight-junction protein and embryonic antigen, is expressed on a variety of tumor cells but is not expressed on normal, healthy adult cells.",
  "synonyms": [
    "autologous Claudin6-targeted CAR-NK cells",
    "autologous CLDN6-CAR-NK cells",
    "autologous anti-CLDN6-CAR-NKs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cldn6-car-nk-cells/"
}