mRNA-encoded anti-CD3/anti-CLDN6 bispecific antibody BNT142

{
  "id": "MLC-T-ONC-015313",
  "term": "mRNA-encoded anti-CD3/anti-CLDN6 bispecific antibody BNT142",
  "field": "Oncology and biomedicine",
  "definition": "A lipid nanoparticle (LNP) encapsulating nucleoside-modified messenger RNA (mRNA) encoding for bispecific antibody directed against the tumor-associated antigen (TAA) Claudin 6 (CLDN6; CLDN-6) and the human T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, mRNA-encoded anti-CD3/anti-CLDN6 bispecific antibody BNT142 binds to the plasma membrane of cells and releases the mRNA into the cells. The mRNA is translated and the anti-CD3/anti-CLDN6 bispecific antibody binds to both CD3-expressing T cells and CLDN6-expressing cancer cells, thereby crosslinking CLDN6-expressing tumor cells and cytotoxic T lymphocytes (CTLs). This results in the activation and proliferation of T cells and causes CTL-mediated cell lysis of CLDN6-expressing tumor cells. CLDN6, a transmembrane tight-junction protein and embryonic antigen, is overexpressed on a variety of tumor cells but is not expressed on normal, healthy adult cells.",
  "synonyms": [
    "RiboMab BNT142",
    "rMAB BNT142",
    "CD3 x CLDN6 mRNA-encoded antibody BNT142",
    "CD3xCLDN6 RiboMAB-encoding mRNA BNT142",
    "anti-CD3/anti-CLDN6 mRNA-encoded antibody BNT142"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mrna-encoded-anti-cd3-anti-cldn6-bispecific-antibody-bnt142/"
}