anti-CLDN6/CD3 bispecific antibody SAIL66

{
  "id": "MLC-T-ONC-010521",
  "term": "anti-CLDN6/CD3 bispecific antibody SAIL66",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific antibody targeting both the tumor-associated antigen (TAA) Claudin 6 (CLDN6; CLDN-6) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, anti-CLDN6/CD3 bispecific antibody SAIL66 targets and binds to both CLDN6 expressed on tumor cells and CD3 expressed on T-cells. This activates and redirects cytotoxic T lymphocytes (CTLs) to CLDN6-expressing tumor cells, which leads to enhanced CTL-mediated killing of CLDN6-expressing tumor cells. CLDN6, a tight-junction protein and embryonic antigen, is expressed on a variety of tumor cells but is not expressed on normal, healthy adult cells.",
  "synonyms": [
    "anti-CLDN6/anti-CD3 bispecific antibody SAIL66",
    "CLDN6 x CD3 bispecific antibody SAIL66"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cldn6-cd3-bispecific-antibody-sail66/"
}