anti-CLDN6 CAR T cells

{
  "id": "MLC-T-ONC-010517",
  "term": "anti-CLDN6 CAR T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of T lymphocytes expressing a chimeric antigen receptor (CAR) targeting the cell surface protein claudin 6 (CLDN6), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CLDN6 CAR T cells specifically target and bind to CLDN6-expressing tumor cells, thereby selectively lysing CLDN6-expressing tumor cells. CLDN-6, a transmembrane tight-junction protein and embryonic antigen, is overexpressed on a variety of tumor cells but is not expressed on normal, healthy adult cells.",
  "synonyms": [
    "CLDN6-targeting CAR T cells",
    "Claudin 6-targeting CAR T cells",
    "anti-Claudin-6 CAR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cldn6-car-t-cells/"
}