mRNA-encoded anti-Claudin18.2 monoclonal antibody BNT141

{
  "id": "MLC-T-ONC-015314",
  "term": "mRNA-encoded anti-Claudin18.2 monoclonal antibody BNT141",
  "field": "Oncology and biomedicine",
  "definition": "A lipid nanoparticle (LNP) encapsulating a messenger RNA (mRNA) encoding for a monoclonal antibody directed against the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, mRNA-encoded anti-claudin18.2 monoclonal antibody BNT141 binds to the plasma membrane of cells and releases the mRNA into the cells. The mRNA is then translated by ribosomes to produce the anti-CLDN18.2 monoclonal antibody. The antibody specifically targets, binds to and inhibits CLDN18.2 expressed on tumor cells. This may kill CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is overexpressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa.",
  "synonyms": [
    "mRNA-encoded antibody BNT141",
    "anti-CLDN18.2 mRNA-encoded antibody BNT141",
    "RiboMab BNT141",
    "rMAB BNT141"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mrna-encoded-anti-claudin18-2-monoclonal-antibody-bnt141/"
}