autologous anti-Claudin18.2-transduced T lymphocytes CT041

{
  "id": "MLC-T-ONC-011414",
  "term": "autologous anti-Claudin18.2-transduced T lymphocytes CT041",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes ex vivo transduced with a lentiviral vector encoding for a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CLDN18.2CAR-transduced T lymphocytes specifically recognize and induce selective toxicity in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein, is expressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa.",
  "synonyms": [
    "autologous CAR-CLD18 T cells",
    "Claudin18.2-redirected autologous T cells",
    "autologous CAR-CLD18.2 T cells",
    "autologous anti-Claudin18.2 CAR-T cells",
    "Claudin18.2-redirected autologous cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-claudin18-2-transduced-t-lymphocytes-ct041/"
}