autologous anti-Claudin18.2 CAR T cells LB1908

{
  "id": "MLC-T-ONC-011413",
  "term": "autologous anti-Claudin18.2 CAR T cells LB1908",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CLDN18.2 CAR T cells LB1908 specifically recognize and induce selective toxicity in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein, is expressed on a variety of tumor cells, but its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa.",
  "synonyms": [
    "autologous anti-CLDN18.2 CAR T cells LB1908",
    "autologous Claudin 18.2-targeting CAR-T cells LB1908",
    "Claudin 18.2-targeted autologous chimeric antigen receptor T cells LB1908"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-claudin18-2-car-t-cells-lb1908/"
}