anti-DLK-1/MMAE antibody-drug conjugate TORL-4-500

{
  "id": "MLC-T-ONC-010569",
  "term": "anti-DLK-1/MMAE antibody-drug conjugate TORL-4-500",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody directed against human delta-like 1 homolog protein (DLK-1; DLK1) conjugated, via a cleavable linker, to the cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration of anti-DLK-1/MMAE ADC TORL-4-500, the anti-DLK-1 antibody moiety targets and binds to DLK-1 expressed on tumor cells. Upon binding, internalization, and linker cleavage, MMAE binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and induces apoptosis in DLK-1-expressing tumor cells. DLK-1, an epidermal growth factor (EGF)-like membrane bound protein overexpressed by certain tumor cell types and on certain cancer stem cells (CSCs), plays a key role in tumor cell proliferation. Its expression is widely expressed during fetal development but in adult healthy tissue it is very restricted.",
  "synonyms": [
    "antibody-drug conjugate TORL-4-500",
    "ADC TORL-4-500",
    "anti-DLK-1 ADC TORL-4-500",
    "anti-DLK-1 antibody-drug conjugate TORL-4-500",
    "anti-DLK-1/MMAE ADC TORL-4-500"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-dlk-1-mmae-antibody-drug-conjugate-torl-4-500/"
}