anti-CD3/anti-GUCY2C bispecific antibody PF-07062119

{
  "id": "MLC-T-ONC-010379",
  "term": "anti-CD3/anti-GUCY2C bispecific antibody PF-07062119",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific antibody against human CD3, a T-cell surface antigen, and human guanylate cyclase 2C (GUCY2C; GCC; guanylyl cyclase C; heat-stable enterotoxin receptor; hSTAR), with potential antineoplastic activity. Upon administration, anti-CD3/anti-GUCY2C bispecific antibody PF-07062119 targets and binds to both CD3 on T cells and GUCY2C expressed on certain tumor cells. This results in the cross-linking of T cells and tumor cells, and induces a cytotoxic T-lymphocyte (CTL) response against GUCY2C-expressing tumor cells. GUCY2C, a transmembrane receptor expressed on intestinal epithelial cells, is overexpressed on certain tumors of the gastrointestinal (GI) tract.",
  "synonyms": [
    "T-cell bispecific antibody PF-07062119",
    "anti-GUCY2C/anti-CD3 bispecific antibody PF-07062119",
    "anti-CD3 x anti-GUCY2C bispecific antibody PF-07062119"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd3-anti-gucy2c-bispecific-antibody-pf-07062119/"
}