anti-CD30/CD3 bispecific antibody GEN3017

{
  "id": "MLC-T-ONC-010333",
  "term": "anti-CD30/CD3 bispecific antibody GEN3017",
  "field": "Oncology and biomedicine",
  "definition": "An Fc-silenced immunoglobulin G1 (IgG1) bispecific monoclonal antibody against the tumor-associated antigen (TAA) CD30 (tumor necrosis factor receptor superfamily member 8; TNFRSF8) and T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD30/CD3 bispecific antibody GEN3017 targets and binds to both CD30 on the surface of tumor cells and CD3 on T cells. This results in the cross-linking of tumor cells and T cells, and induces a cytotoxic T-lymphocyte (CTL) response against CD30-expressing tumor cells. CD30, a member of the tumor necrosis factor receptor superfamily, is overexpressed on the surfaces of certain tumor cells.",
  "synonyms": [
    "anti-CD30/anti-CD3 bispecific antibody GEN3017",
    "CD30 x CD3 bispecific antibody GEN3017",
    "DuoBody CD3xCD30 GEN3017",
    "DuoBody GEN3017"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd30-cd3-bispecific-antibody-gen3017/"
}