CD30 CAR-expressing autologous T lymphocytes

{
  "id": "MLC-T-ONC-012394",
  "term": "CD30 CAR-expressing autologous T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the CD30 antigen, with potential immunostimulating and antineoplastic activities. Upon administration, the CD30 CAR-expressing autologous T lymphocytes specifically recognize and bind to CD30-expressing tumor cells, resulting in tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies.",
  "synonyms": [
    "CAR.CD30-expressing autologous T lymphocytes",
    "anti-CD30 CAR-expressing autologous T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cd30-car-expressing-autologous-t-lymphocytes/"
}