Allogeneic anti-CD30 CAR-Epstein-Barr virus-specific T lymphocytes

{
  "id": "MLC-T-ONC-009816",
  "term": "Allogeneic anti-CD30 CAR-Epstein-Barr virus-specific T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic human Epstein-Barr virus (EBV)-specific T lymphocytes (EBVSTs) that have been genetically modified to express a chimeric antigen receptor (CAR) recognizing the tumor-associated antigen (TAA) cluster of differentiation 30 (CD30), with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-CD30 CAR-EBVSTs specifically recognize and bind to CD30-expressing EBV-infected tumor cells, resulting in tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies. EBV, a ubiquitous human herpes virus, is associated with various malignancies, including nasopharyngeal carcinoma, Hodgkin disease, non-Hodgkin lymphoma, and other lymphomas.",
  "synonyms": [
    "allogeneic CD30.CAR-EBVSTs",
    "allogeneic anti-CD30 CAR EBV-specific T lymphocytes",
    "allogeneic anti-CD30 CAR-EBVSTs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-anti-cd30-car-epstein-barr-virus-specific-t-lymphocytes/"
}