allogeneic Epstein-Barr virus-specific cytotoxic T lymphocytes

{
  "id": "MLC-T-ONC-009882",
  "term": "allogeneic Epstein-Barr virus-specific cytotoxic T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic Epstein-Barr virus (EBV) specific cytotoxic T lymphocytes (CTL) with potential antineoplastic activity. Upon administration, the allogeneic EBV-specific CTLs are either harvested from a donor with an EBV-positive tumor or are donor CTLs activated against EBV-specific antigens ex vivo. Administration into a patient exerts a CTL response against EBV-positive tumor cells or EBV-infected cells. This results in cell lysis and inhibition of cancer cell proliferation. EBV, a ubiquitous human herpes virus, is associated with various malignancies, including nasopharyngeal carcinoma, Hodgkin disease, non-Hodgkin lymphoma, and other lymphomas.",
  "synonyms": [
    "allogeneic EBV-specific CTL"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-epstein-barr-virus-specific-cytotoxic-t-lymphocytes/"
}