CD137L/Epstein-Barr virus-targeting autologous dendritic cell vaccine

{
  "id": "MLC-T-ONC-012365",
  "term": "CD137L/Epstein-Barr virus-targeting autologous dendritic cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cell-based cancer vaccine composed of in vitro generated, highly potent, CD137 ligand (CD137L)-dendritic cells (CD137L-DCs), pulsed with Epstein-Bar Virus (EBV) antigen peptides, with potential antineoplastic and immunostimulatory activities. Upon administration, CD137L-DCs induce potent CD8+ T-cell responses against EBV+ target cells. DCs stimulated with CD137L enhance cytotoxic T-lymphocyte proliferation and activation to a greater extent compared to non-CD137L-stimulated DCs.",
  "synonyms": [
    "CD137L-DC-EBV-VAX",
    "CD137L/Epstein-Barr virus-targeting autologous DC vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cd137l-epstein-barr-virus-targeting-autologous-dendritic-cell-vaccine/"
}