C7R-expressing EBVSTs

{
  "id": "MLC-T-ONC-012178",
  "term": "C7R-expressing EBVSTs",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of human Epstein-Barr virus (EBV)-specific T lymphocytes (EBVSTs) that have been genetically modified to express the constitutively active interleukin 7 (IL-7) receptor (C7R; IL-7R), with potential immunostimulating and antineoplastic activities. Upon administration, the CR7-expressing EBVSTs specifically recognize and bind EBV-infected tumor cells, resulting in tumor cell lysis. EBV, a ubiquitous human herpes virus, is associated with various malignancies, specifically nasopharyngeal carcinoma and lymphomas, including Hodgkin and non-Hodgkin. C7R triggers IL-7-mediated signaling that promotes T-cell proliferation and survival. The enhanced T-cell survival prolongs EBV-infected tumor cell killing and anti-tumor activity.",
  "synonyms": [
    "C7R modified EBV specific T lymphocytes",
    "C7R-EBV T cells",
    "C7R-expressing EBV-specific T lymphocytes",
    "C7R-expressing Epstein-Barr virus-specific T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/c7r-expressing-ebvsts/"
}