PD-1 knockout EBV-specific cytotoxic T lymphocytes

{
  "id": "MLC-T-ONC-015877",
  "term": "PD-1 knockout EBV-specific cytotoxic T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of Epstein-Barr virus (EBV) reactive cytotoxic T lymphocytes (CTLs) in which the programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1) gene is deleted, with potential immunomodulating activity. Upon administration of the PD-1 knockout EBV-specific CTLs, these CTLs target and induce selective toxicity in EBV-positive cancer cells. This results in cell lysis and inhibition of cancer cell proliferation. Expression of PD-1, an inhibitory receptor expressed on activated T cells, plays a key role in CTL suppression, T-cell exhaustion and CTL apoptosis. PD-1 knockout abrogates T-cell exhaustion and increases T-cell activity and cytotoxicity. EBV, a ubiquitous human herpesvirus, is associated with various cancer cell types.",
  "synonyms": [
    "PD-1 knockout EBV-CTLs",
    "PD-1 knockout Epstein-Barr virus-cytotoxic T lymphocytes",
    "PD-1 knockout EBV-reactive CTLs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pd-1-knockout-ebv-specific-cytotoxic-t-lymphocytes/"
}