PD-1 knockout autologous T lymphocytes

{
  "id": "MLC-T-ONC-015876",
  "term": "PD-1 knockout autologous T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A population of engineered autologous T lymphocytes in which the gene encoding for the programmed cell death protein 1 (PDCD-1) is deleted, with potential immunomodulating activity. Following collection of peripheral blood lymphocytes and selection of T cells, the PDCD-1 gene was knocked out and the T cells were expanded. Upon reinfusion of the PDCD-1 knockout T lymphocytes, these T cells target and lyse cancer cells. The PDCD-1 protein, found on activated T cells and often overexpressed on T cells in cancer patients, negatively regulates T-cell activity; it plays a key role in immune evasion and prevents tumor cell lysis. PDCD-1 knockout enhances cytotoxicity and T-cell-mediated anti-tumor immune responses.",
  "synonyms": [
    "PD-1-disrupted autologous T lymphocytes",
    "PD-1 knockout autologous T cells",
    "PDCD1 gene knockout autologous T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pd-1-knockout-autologous-t-lymphocytes/"
}