Autologous PD1-knockout CD19-specific CAR T cells

{
  "id": "MLC-T-ONC-011743",
  "term": "Autologous PD1-knockout CD19-specific CAR T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous CD4+ and CD8+ T lymphocytes gene-edited to integrate a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and to eliminate the programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1) gene, with potential immunomodulating and antineoplastic activities. Upon administration, autologous PD1-knockout CD19-specific CAR T cells specifically target and bind to CD19-expressing tumor cells, thereby selectively lysing CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. Expression of PD-1, an inhibitory receptor expressed on activated T cells, plays a key role in CTL suppression, T-cell exhaustion and CTL apoptosis. PD-1 knockout may abrogate T-cell exhaustion and increase T-cell activity and cytotoxicity.",
  "synonyms": [
    "CD19-CAR T Cells with PD1 Knockout",
    "autologous quikin-CD19-CART"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-pd1-knockout-cd19-specific-car-t-cells/"
}