autologous PD-1-knockout tumor-infiltrating lymphocytes IOV-4001

{
  "id": "MLC-T-ONC-011745",
  "term": "autologous PD-1-knockout tumor-infiltrating lymphocytes IOV-4001",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous tumor-infiltrating lymphocytes (TILs) where the programmed cell death protein 1 (PD-1; PDCD1; CD279; programmed death-1) gene has been disrupted using transcription activator-like effector nuclease (TALEN), with potential immunomodulating and antineoplastic activities. The autologous TILs are isolated from an autologous tumor sample, expanded ex-vivo and genetically modified to inactivate PD-1. Upon administration, the autologous PD-1-knockout TILs IOV-4001 induce a T-cell-mediated immune response against tumor cells. Expression of PD-1, an inhibitory receptor expressed on activated T cells, plays a key role in cytotoxic T-lymphocyte (CTL) suppression, T-cell exhaustion and CTL apoptosis. PD-1 knockout may abrogate T-cell exhaustion and increase T-cell activity and cytotoxicity.",
  "synonyms": [
    "autologous PD-1-knockout TILs IOV-4001",
    "autologous PDCD1-knockout tumor-infiltrating lymphocytes IOV-4001",
    "autologous PDCD1 KO TILs IOV-4001",
    "autologous PDCD1-knockout TILs IOV-4001"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-pd-1-knockout-tumor-infiltrating-lymphocytes-iov-4001/"
}