autologous PRAME-targeting TCR-modified T cells MDG1011

{
  "id": "MLC-T-ONC-011753",
  "term": "autologous PRAME-targeting TCR-modified T cells MDG1011",
  "field": "Oncology and biomedicine",
  "definition": "Human autologous T lymphocytes transduced with a retroviral vector encoding a human leukocyte antigen (HLA)-A*02:01-restricted T-cell receptor (TCR) specific for the human tumor-associated antigen (TAA) preferentially expressed antigen in melanoma (PRAME) coupled to the CD3 signaling complex, with potential antineoplastic activity. Upon reintroduction into the patient, the autologous PRAME-targeting TCR-modified T cells MDG1011 target and bind to tumor cells expressing PRAME. This may induce cell death in and halt the growth of PRAME-expressing tumor cells. The TAA PRAME is overexpressed by a variety of cancer cell types.",
  "synonyms": [
    "autologous anti-PRAME-TCR-expressing T cells MDG1011",
    "autologous TCR-modified T cells MDG1011",
    "autologous PRAME TCR-modified T cells MDG1011",
    "PRAME-TCR gene-modified autologous T cells MDG1011"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-prame-targeting-tcr-modified-t-cells-mdg1011/"
}