anti-PRAME T-cell receptor/anti-CD3 scFv fusion protein IMC-F106C

{
  "id": "MLC-T-ONC-011042",
  "term": "anti-PRAME T-cell receptor/anti-CD3 scFv fusion protein IMC-F106C",
  "field": "Oncology and biomedicine",
  "definition": "A T-cell re-directing bi-specific biologic composed of a modified form of human T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) preferentially expressed antigen in melanoma (PRAME) and fused to an anti-CD3 single-chain variable fragment (scFv), with potential antineoplastic activity. Upon administration of IMC-F106C, the TCR moiety of this agent targets and binds to PRAME on tumor cells and the anti-CD3 scFv moiety binds to CD3- expressing T lymphocytes. This selectively cross-links tumor cells and T lymphocytes and results in a CTL-mediated death of PRAME-expressing tumor cells. The TAA PRAME is overexpressed by a variety of cancer cell types.",
  "synonyms": [
    "ImmTAC IMC-F106C",
    "immune mobilizing monoclonal TCR against cancer IMC-F106C",
    "ImmTAC molecule IMC-F106C"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-prame-t-cell-receptor-anti-cd3-scfv-fusion-protein-imc-f106c/"
}