anti-PRL-3 monoclonal antibody PRL3-zumab

{
  "id": "MLC-T-ONC-011043",
  "term": "anti-PRL-3 monoclonal antibody PRL3-zumab",
  "field": "Oncology and biomedicine",
  "definition": "A humanized monoclonal antibody against phosphatase of regenerating liver 3 (PRL-3; PTP4A3), with potential immunomodulating and antineoplastic activities. Upon administration, anti-PRL-3 monoclonal antibody PRL3-zumab targets, binds to and blocks PRL-3 expressed on tumor cells. Although the exact mechanism of action through which this antibody kills tumor cells has yet to be fully elucidated, PRL3-zumab binds to PRL-3. This prevents PRL-3-mediated signaling in, inhibits the proliferation of and induces apoptosis in PRL-3-expressing tumor cells. PRL-3, a member of the PRL family of protein tyrosine kinases, is upregulated in a variety of tumor cells. Its expression is associated with increased invasiveness, higher metastatic potential, increased tumor cell survival and poor prognosis.",
  "synonyms": [
    "PRL3-zumab",
    "PRL3 zumab"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-prl-3-monoclonal-antibody-prl3-zumab/"
}