anti-prolactin receptor antibody LFA102

{
  "id": "MLC-T-ONC-011046",
  "term": "anti-prolactin receptor antibody LFA102",
  "field": "Oncology and biomedicine",
  "definition": "A neutralizing antibody against the prolactin receptor (PRLR) with potential antineoplastic activity. Upon administration, anti-prolactin receptor antibody LFA102 binds to PRLR and prevents the binding of the peptide hormone prolactin (PRL) to its receptor. This binding induces an antibody-dependent cellular cytotoxicity (ADCC) and may eventually prevent tumor cell proliferation in PRLR-positive cancer cells. PRLR/PRL signaling pathway is frequently overexpressed in breast and prostate cancer.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-prolactin-receptor-antibody-lfa102/"
}