Teglarinad chloride

{
  "id": "MLC-T-ONC-017044",
  "term": "Teglarinad chloride",
  "field": "Oncology and biomedicine",
  "definition": "A water-soluble prodrug of a cyanoguanidine compound with potential antineoplastic activity. In vivo, teglarinad chloride is rapidly converted into active drug through hydrolytic cleavage of a carbonate ester bond. Although the exact mechanism of action has yet to be fully elucidated, the active drug appears to antagonize nuclear factor-kappa B (NF-kB) transcription, resulting in the induction of tumor cell apoptosis.",
  "synonyms": [
    "apoptosis inducer GMX1777"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/teglarinad-chloride/"
}