topiramate

{
  "id": "MLC-T-ONC-017263",
  "term": "topiramate",
  "field": "Oncology and biomedicine",
  "definition": "A sulfamate-substituted monosaccharide with anticonvulsant activity. Although the mechanism of action has not been fully elucidated, topiramate appears to antagonize kainate/AMPA subtype glutamate receptors, which results in stabilization of hyper-excited neural membranes, inhibition of repetitive neuronal firing, and a decrease in propagation of synaptic impulses, thus impeding seizure activity. In addition, this agent enhances chloride channels activated by the inhibitory neurotransmitter GABA. Kainate/AMPA subtype glutamate receptors are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/topiramate/"
}