topoisomerase I inhibitor Genz-644282

{
  "id": "MLC-T-ONC-017264",
  "term": "topoisomerase I inhibitor Genz-644282",
  "field": "Oncology and biomedicine",
  "definition": "A non-camptothecin inhibitor of topoisomerase I with potential antineoplastic activity. Topoisomerase I inhibitor Genz-644282 binds to and inhibits the enzyme topoisomerase I, which may result in the inhibition of repair of single-strand DNA breaks, DNA replication, and tumor cell growth in susceptible tumor cell populations.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/topoisomerase-i-inhibitor-genz-644282/"
}