edotecarin

{
  "id": "MLC-T-ONC-002677",
  "term": "edotecarin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance being studied in the treatment of cancer. It is a type of topoisomerase I inhibitor. Also called J-107088.",
    "A synthetic indolocarbazole with antineoplastic activity. Edotecarin inhibits the enzyme topoisomerase I through stabilization of the DNA-enzyme complex and enhanced single-strand DNA cleavage, resulting in inhibition of DNA replication and decreased tumor cell proliferation."
  ],
  "synonyms": [
    "J-107088",
    "PHA-782615"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/edotecarin/"
}