topoisomerase I inhibitor LMP400

{
  "id": "MLC-T-ONC-017265",
  "term": "topoisomerase I inhibitor LMP400",
  "field": "Oncology and biomedicine",
  "definition": "An indenoisoquinoline and non-camptothecin inhibitor of topoisomerase I (Top I) with potential antineoplastic activity. Topoisomerase I inhibitor LMP400 binds to the topoisomerase I-DNA covalent cleavage complexes, and inhibits repair of single-strand DNA breaks, DNA replication, and tumor cell growth in susceptible tumor cell populations. Compared to camptothecins, indenoisoquinolines are chemically stable, produce stable Top I-DNA cleavage complexes, induce unique DNA cleavage sites and appear more resistant to multidrug efflux pumps.",
  "synonyms": [
    "Top1 inhibitor 400"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/topoisomerase-i-inhibitor-lmp400/"
}