Topoisomerase-1 inhibitor LMP744

{
  "id": "MLC-T-ONC-017268",
  "term": "Topoisomerase-1 inhibitor LMP744",
  "field": "Oncology and biomedicine",
  "term_source": "Topoisomerase-1 Inhibitor LMP744",
  "definition": "An indenoisoquinoline derivative and topoisomerase 1 (Top1) inhibitor, with potential antineoplastic activity. Upon administration, LMP744 binds to and stabilizes cleaved DNA-Top1 complexes, which prevents DNA re-ligation, induces stable, irreversible DNA strand breaks, prevents DNA repair, and leads to cell cycle arrest and apoptosis. As tumor cells proliferate at a much higher rate than normal cells, LMP744 specifically targets cancer cells. Top1, a DNA modifying enzyme essential for transcription, replication, and repair of double-strand DNA breaks, is overexpressed in tumor cells.",
  "synonyms": [
    "indenoisoquinoline LMP744"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/topoisomerase-1-inhibitor-lmp744/"
}