pegylated TOP1 inhibitor PEEL-224

{
  "id": "MLC-T-ONC-015933",
  "term": "pegylated TOP1 inhibitor PEEL-224",
  "field": "Oncology and biomedicine",
  "definition": "A pegylated camptothecin derivative, with potential antineoplastic activity. Upon administration of pegylated TOP1 inhibitor PEEL-224, camptothecin reaches the tumor cells and selectively stabilizes covalent topoisomerase I-DNA complexes, which results in single-stranded and double-stranded DNA breaks, the inhibition of DNA replication, and the induction of apoptosis. Pegylation allows for increases in half-life and the exposure time for tumor cells, while decreasing both blood plasma concentrations and exposure to off-target organs. This may increase efficacy and reduce systemic toxicities.",
  "synonyms": [
    "topoisomerase-I inhibitor PEEL-224"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pegylated-top1-inhibitor-peel-224/"
}