Polyglutamate camptothecin

{
  "id": "MLC-T-ONC-006796",
  "term": "Polyglutamate camptothecin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A form of the anticancer drug camptothecin that may have fewer side effects and work better than camptothecin. It is being studied in the treatment of cancer. It is a type of DNA topoisomerase inhibitor. Also called CT-2106.",
    "A therapeutic formulation consisting of camptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminata, conjugated with polyglutamate. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. Conjugation with polyglutamate renders this agent more water soluble and less toxic than the parent molecule."
  ],
  "abbreviation": "PG-CPT",
  "synonyms": [
    "CT-2106"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/polyglutamate-camptothecin/"
}