poly-ICLC

{
  "id": "MLC-T-ONC-006797",
  "term": "poly-ICLC",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance that is being studied in the treatment of cancer and for its ability to stimulate the immune system. It is made in the laboratory by combining the nucleic acid RNA with the chemicals poly-L-lysine and carboxymethyl cellulose.",
    "A synthetic complex of carboxymethylcellulose, polyinosinic-polycytidylic acid, and poly-L-lysine double-stranded RNA. Poly ICLC may stimulate the release of cytotoxic cytokines and, by inducing interferon-gamma production, may increase the tumoricidal activities of various immunohematopoietic cells."
  ],
  "expansions": [
    "stabilized polyriboinosinic/polyribocytidylic acid",
    "polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose",
    "polyriboinosinic-polyribocytidylic acid-polylysine carboxymethylcellulose"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/poly-iclc/"
}