nanoplexed poly I:C BO-112

{
  "id": "MLC-T-ONC-015430",
  "term": "nanoplexed poly I:C BO-112",
  "field": "Oncology and biomedicine",
  "definition": "A synthetic double-stranded RNA (dsRNA) polyinosinic:polycytidylic acid (poly I:C) nanoplexed with the cationic carrier polyethylenimine (PEI), with potential immunostimulating and antineoplastic activities. Upon intratumoral administration, nanoplexed poly I:C BO-112, which mimics viral RNAs, may stimulate the release of cytotoxic cytokines and induces interferon-gamma production. This may increase the tumoricidal activities of various immunohematopoietic cells. The PEI carrier enhances the delivery of the agent into the cells.",
  "synonyms": [
    "nanoplexed polyinosinic:polycytidylic acid BO-112"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/nanoplexed-poly-i-c-bo-112/"
}