MLchartDataset catalogue

Poly ICLC

Term · Chemistry · MLC-T-CHM-009091

A synthetic double-stranded RNA complex of polyinosinic-polycytidylic acid stabilized with poly-L-lysine and carboxymethylcellulose. This modification enhances its stability and reduces its degradation by nucleases, allowing for prolonged immunostimulatory effects. Poly ICLC acts as a potent inducer of interferon and is investigated for its antiviral and antitumor properties.

Table 1. Record
IdentifierMLC-T-CHM-009091
FieldChemistry
SubjectChemistry and Human Health
ReferencesPAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1232 (https://doi.org/10.1351/PAC-REC-11-06-03)
Record as JSON
{
  "id": "MLC-T-CHM-009091",
  "term": "Poly ICLC",
  "field": "Chemistry",
  "definition": "A synthetic double-stranded RNA complex of polyinosinic-polycytidylic acid stabilized with poly-L-lysine and carboxymethylcellulose. This modification enhances its stability and reduces its degradation by nucleases, allowing for prolonged immunostimulatory effects. Poly ICLC acts as a potent inducer of interferon and is investigated for its antiviral and antitumor properties.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1232 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/poly-iclc/"
}

Record 9,652 of 13,676 in Chemistry terminology (MLC-0109). Request the full dataset.