Small inhibitory double-stranded RNA

{
  "id": "MLC-T-CHM-010946",
  "term": "Small inhibitory double-stranded RNA",
  "field": "Chemistry",
  "definition": "A synthetic or endogenously produced double-stranded RNA molecule, typically 20-25 nucleotides in length, that mediates RNA interference (RNAi). This molecule guides the RNA-induced silencing complex (RISC) to target messenger RNA (mRNA) sequences, leading to their degradation or translational repression. It is a tool for gene silencing in research and has therapeutic potential.",
  "synonyms": [
    "small interfering double-stranded RNA"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "molecular target"
  ],
  "references": [
    "PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1751 (https://doi.org/10.1351/PAC-REC-12-11-23)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/small-inhibitory-double-stranded-rna/"
}