oral topotecan hydrochloride

{
  "id": "MLC-T-ONC-015704",
  "term": "oral topotecan hydrochloride",
  "field": "Oncology and biomedicine",
  "definition": "An oral formulation of the hydrochloride salt of topotecan, a semisynthetic derivative of the quinoline alkaloid camptothecin, with potential antineoplastic activity. Topotecan selectively inhibits topoisomerase I activity by stabilizing topoisomerase I-DNA covalent complexes during the S phase of the cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery.",
  "synonyms": [
    "oral hycamtin"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/oral-topotecan-hydrochloride/"
}